郭麗霞
c7c7.app藥學院藥物化學教研室，講師，理學博士
E-mail:guolxia@sxmu.edu.cn
教育經歷
2015年9月—2020年7月 山西大學，博士（碩博連讀）
2011年9月—2015年7月 太原師范學院，學士
工作經歷
2022年3月—至今 在站博士后，c7c7.app第三臨床醫學院
2020年9月—至今 c7c7.app，藥學院，講師
榮譽獲獎
山西省自然科學二等獎，山西省科技廳，2022
教學情況
主要承擔承擔了《有機化學》、《化學生物學》《藥學進展》的教學，以及有機化學和藥物化學的實驗準備工作。
研究領域
聚焦于有機功能分子的設計、合成，以及納米自組裝體的構建，致力于其在疾病診斷、抗菌領域的應用。在有機功能分子設計合成方面，構建具有特定光學、電學或化學活性的有機分子，利用其對生物標志物的特異性識別能力，實現疾病的早期精準診斷；設計合成具有抗菌活性的有機分子及納米自組裝體，探索其對耐藥菌的作用機制，為解決抗生素耐藥問題提供新思路。
代表性科研、教改項目
1、中國博士后科學基金面上資助，中國博士后科學基金會，8萬元，在研，主持。
2、山西省博士啟動基金，5萬，在研，主持。
3、山西省自然科學基金青年項目，山西省科技廳，5萬元，結題，主持。
代表性論著
1、發表論文：
(1) Lixia Guo, Xiaowan Li, Run Zhang, Yixuan Hou, Bolong Ma, Zheng Li, Jiye Lv, Bin Wang, Sufang Ma, Lihong Li, Lili Yan, Boye Zhang, Wen Liu, Kahleong Lim, Haipeng Diao*, Shaowei Wang*, Chengwu Zhang*. In situ dual-activated NIRF/PA carrier-free nanoprobe for diagnosis and treatment of Parkinson’s disease. Biosensors and Bioelectronics, 2025, 282, 117473.
(2) Lixia Guo, Xiaowan Li, Shangyu Xie, Baizhi Su, Na Yang, Bin Wang, Sufang Ma, Lihong Li, Lili Yan, Boye Zhang, Wen Liu, Kahleong Lim, Yang Liu*, Haipeng Diao*, Chengwu Zhang*. Double-locked probe for NIRF/PA imaging mitochondrial H2O2 and viscosity in Parkinson’s disease. Sensors & Actuators: B. Chemical, 2025, 205, 111370.
(3) Lixia Guo, Yafei Tian, Liang Zhou, Shiyue Kang, Chengwu Zhang, Wen Liu, Haipeng Diao, Liheng Feng. Tailored phototherapy agent by infection site in situ activated against methicillin-resistant S. aureus. Advanced Healthcare Materials, 2024, 2400593.
(4) Lixia Guo, Jiahuan Liu, Xiaowan Li, Yinyu Ma, Shiyue Kang, Yafei Tian, Bin Wang, Sufang Ma, Lihong Li, Lili Yan, Chengwu Zhang, Wen Liu, Haipeng Diao*, Shurong Ban*, Ruiping Zhang*, Liheng Feng*. An activatable NIR fluorescent/photoacoustic probe for rapid identification of β-lactam-resistant bacteria，Microchemical Journal, 2024, 205, 111368.
(5) Jiahuan Liu, Xiaowan Li, Shangyu Xie, Ruirui Ma, Hongfei Wang, Shurong Ban*, Chengwu Zhang*, Lixia Guo*. Fabricating a PDA-NOate@CuS coated NIR-activatable titanium implant to realize simultaneous antiinfection and osseointegration. New Journal of Chemistry, 2024, 48, 11465-11475.
(6) Lixia Guo, Xueyun Zhang, Danning Wen, Lei Ding, Yan Niu, Lihong Li, Wen Liu, Haipeng Diao*, Liheng Feng*. A Novel Two-channel Ratio Fluorescent Probe for Monitoring Intracellular pH Fluctuations. Sensors and Actuators B: Chemical, 2022, 360, 131656.
(7) Lixia Guo, Haoping Wang, Yunxia Wang*, Feng Liu*, Liheng Feng*. Organic Polymer Nanoparticles with Primary Ammonium Salt as Potent Antibacterial Nanomaterials. ACS Applied Materials & Interfaces, 2020, 12, 21254?21262.
(8) Lixia Guo, Haoping Wang, Yunxia Wang*, Liheng Feng*. Tailor-Made Polymer Nano-Assembly with Switchable Function and Amplified Anti-Tumor Therapy. Advanced Healthcare Materials, 2019, 1901492.
(9) Lixia Guo, Haoping Wang, Yunxia Wang*, Liheng Feng*. Facile core-shell nanoparticles with controllable antibacterial activity assembled by chemical and biological molecules. Biomaterials Science, 2019, 7, 5528-5534.
(10) Lixia Guo, Xiaoju Wang, Liheng Feng*. Synthesis, photophysical and electrochemical properties of a blue emitter with binaphthalene and carbazole units. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 201, 376-381.
(11) Liheng Feng*, Lixia Guo, Xiaoju Wang. Preparation, properties and applications in cell imaging and ions detection of conjugated polymer nanoparticles with alcoxyl bonding fluorene core. Biosensors and Bioelectronics, 2017, 87, 514-521.
(12) Xiaoju Wang#, Lixia Guo#, Liheng Feng*. A multi stimuli responsive material with rhodamine B and carbazole groups. New Journal of Chemistry, 2019, 43, 4181-4187.
(13) Tao Qin#, Lixia Guo#, Haipeng Diao*, Liheng Feng*. Facile Antibacterial Materials with Turbine-like Structure for P. aeruginosa Infected Scald Wounds Healing. Biomaterials Science, 2021, 9, 3830.
2、授權專利
(1) 郭麗霞，劉文，田亞飛，李錦瑤，任國棟，馬素芳，張承武，李麗紅，刁海鵬，王浩江，王斌，閆麗麗. 一種檢測耐藥菌中β-內酰胺酶的近紅外熒光探針的制備, 專利號：ZL202211255743.4，授權日：2023-08-29。
(2) 郭麗霞，馮麗恒. 具有可視化診斷和治療感染傷口的溫敏水凝膠及制備方法，專利號：ZL201911364220.1，授權日：2021.3.30。
(3) 馮麗恒，郭麗霞. 一種藍光發光材料及其制備方法. 國內發明專利，專利號：ZL201610200923.0，授權日：2017.11.3。
(4) 馮麗恒，郭麗霞. 一種環狀聚合物及其制備方法和應用. 國內發明專利，專利號：ZL201810189654.1，授權日：2020.2.14。
