成曉龍
c7c7.app，基礎醫學院，教授
教育經歷（從大學本科開始，按時間倒序排序；請列出攻讀研究生學位階段導師姓名）：
1.2001/9–2004/7， c7c7.app， 生理學， 博士， 導師：趙榮瑞
2.1994/9–1997/7， c7c7.app， 人體解剖與組織胚胎學， 碩士，
導師：王紹坤
3.1989/9–1994/7， 山西醫學院， 臨床醫學， 學士 ;
科研與學術工作經歷（按時間倒序排序；如為在站博士后研究人員或曾進入博士后流動站（或工作站）從事研究，請列出合作導師姓名）：
1.2010/1 -至今，c7c7.app，基礎醫學院，教授
2.2004/9-2010/1，c7c7.app，基礎醫學院，副教授
3.1999/7-2004/8，c7c7.app，基礎醫學院，講師
4.1997/7-1999/6，c7c7.app，基礎醫學院，助教
曾使用其他證件信息（申請人應使用唯一身份證件申請項目，曾經使用其他身份證件作為申請人或主要參與者獲得過項目資助的，應當在此列明）：主持或參加科研項目（課題）及人才計劃項目情況（按時間倒序排序）：
1.國家自然科學基金面上項目,81672768,AJUBA基因在食管癌中的作用及機制研究, 2017/01-2020/12，73萬，在研，主持；
2. 山西省高等學校優秀創新團隊項目，2015-0101，2015年度山西省高等學校優秀創新團隊，2016/01-2018/12，100萬元，結題，參加；
3.山西省回國留學人員科研資助重點項目，2015-重點3，食管癌分子分型及耐藥特異分子標記的篩選鑒定，2015/01-2018/12，30萬元，結題，參加；
4.國家自然科學基金重點項目，81330063，食管鱗癌異質性及耐藥機制的多組學貫穿分析研究，2014/01-2018/12，290萬元，結題，參加；
6.山西省科技創新團隊項目，2013-23，消化系統惡性腫瘤防治創新團隊，2014/01-2015/12，20萬元，結題，參加；
7.國家自然科學基金面上項目，81272694，ECRG2 基因在食管癌等常見惡性腫瘤中的突變、功能分析及臨床意義評價， 2013/1-2016/12 ，55萬元，結題，主持；
8.山西省重點學科建設專項經費，晉財教[2012]143號，惡性腫瘤發病機制、早期診斷標記物及靶向治療，2013/01-2015/12，160萬元，結題，參加。
9.國家自然科學基金面上項目，81071625，食管癌相關基因2在腫瘤形成、轉移、治療中的作用及最小功能結構域的鑒定， 2011/01-2013/12，31萬元，結題，主持；
10. 山西省強校工程高等學校優秀青年學術帶頭人支持計劃，晉教科[2008]3號，食管癌相關基因研究， 2009/1- 2011/12 ，20萬元，結題，主持；
代表性研究成果和學術獎勵情況（每項均按時間倒序排序）
一、期刊論文
1.通信作者論文（勿與第一作者論文重復）
(1)Yu Qian#, Xiao Liang#, Pengzhou Kong#, Yikun Cheng, Heyang Cui, Ting Yan, Jinghao Wang, Ling Zhang,Yiqian Liu, Shiping Guo,Xiaolong Cheng*and Yongping Cui*, Elevated DHODH expression promotes cellproliferation via stabilizing β-catenin in esophagealsquamous cell carcinoma, Cell Death and Disease,2020 11:862
(2)Ling Zhang#, Yingzhen Gao#, Xiaojuan Zhang#, Min Guo#, Jie Yang#, Heyang Cui, Pengzhou Kong,Xia Niu, Yanghui Bi, Jing Xu, Ting Yan, Yanchun Ma, Jian Yang, Yu Qian, Fang Wang, Hongyi Li,Feng Liu,Xiaolong Cheng*and Yongping Cui*. TSTA3 facilitates esophageal squamous cell carcinomaprogression through regulating fucosylation of LAMP2and ERBB2,Theranostics,2020; 10(24): 11339-11358
(3) Pengzhou Kong#, Enwei Xu#, Yanghui Bi#, Xiaoqin Xu#, Xue Liu#, Bin Song, Ling Zhang, Caixia Cheng, Ting Yan, Yu Qian, Jian Yang, Yanchun Ma, Heyang Cui, Yuanfang Zhai, Binbin Zou, Xiangchen Liu, Yikun Cheng, Shiping Guo,Xiaolong Cheng*, and Yongping Cui*,Novel ESCC-related gene ZNF750 as potential Prognostic biomarker and inhibits Epithelial-Mesenchymal Transition through directly depressing SNAI1 promoter in ESCC,Theranostics,2020,10(4): 1798-1813.
(4) Yanghui Bi#, Shixing Guo#, Xiaoqin Xu#, Pengzhou Kong#, Heyang Cui#,Ting Yan#,Yanchun Ma#, Yikun Cheng#, Yunqing Chen#, Xue Liu, Ling Zhang, Caixia Cheng, Enwei Xu, Yu Qian, Jian Yang, Bin Song, Hongyi Li, Fang Wang, Xiaoling Hu, Xiangchen Liu, Xia Niu, Yuanfang Zhai, Jing Liu, Yaoping Li,Xiaolong Cheng*, and Yongping Cui*,Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma,Cell Death & Disease,2020, In press.
(5) Ling Zhang#, Xia Niu, Yanghui Bi, Heyang Cui, Hongyi Li, andXiaolong Cheng*,Potential Role of Targeting KDR andProteasome Inhibitors in the Therapy ofEsophageal Squamous Cell Carcinoma,Technology in Cancer Research &Treatment,2020; 19: 1533033820948060
(6)Jian Yang#，Xiao Liang#，Yuanfang Zhai，Xiaoling Hu，Zhiwu Jia，Xiaolong Cheng*,Considering gemcitabine-based combination chemotherapyas a potential treatment for advanced oesophageal cancer: Ameta-analysis of randomised trials,THE INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2020,74(7):e13510
(7)XiaolingHu#,YuanfangZhai#, RuyiShi#, YuQian#, HeyangCui,JieYang, YanghuiBi,TingYan,JieYang,YanhunMa,LingZhang,Yinqian Liu,GuodongLI,MingshengZhang,YongpingCui, PengzhouKong*,XiaolongCheng*, FAT1 inhibits cell migration and invasion via effecting cellular mechanical properties in esophageal squamous cell carcinoma, Oncology reports,2018; 39(5):2136-2146.
(8)RuyiShi#,HeyangCui#,YanghuiBi#,XunHuang#,BinSong,CaixiaCheng,LingZhang,JingLiu,ChantingHe,FangWang,ZhiwuJia,BinYang,JuanWang,JinyaoDong,ZhijieDu,ShuaishuaiXiao,YongpingCui,XiaolongCheng*,Artesunate altered cellular mechanical properties leading to deregulation ofcell proliferation and migration in esophageal squamous cellcarcinoma,Oncology Letters,2015,9(5):2249-2255.
(9)趙志平#，劉靜，李曙晶，鄒麗，繆小平，成曉龍*，FASL-844T/C多態性與宮頸癌易感性的Meta分析，中國婦幼保健,2013,28(17):2828-2830。
(10)宋彬#，劉靜，史衛?。院推?，賈軍梅，柯俊濤，繆小平，成曉龍*,TOX3
基因單核苷酸多肽與乳腺癌風險的相關性Meta分析,中國藥物與臨床,2013,13(10):1252-1255。
(11)李曙晶#，張燕燕，劉靜，張玲，師如意，趙志平，賀嬋婷，成曉龍*，癌基因B-RafV600E導致黑色素瘤Sbcl2和SK-MEL31細胞染色體不穩定性的分子機制研究，腫瘤研究與臨床，2012,24(9):589-592。
(12)馬林梅#，劉靜，李曙晶，史衛?。蘩?，繆小平，成曉龍*，FAS-670A/G多態性與宮頸癌易感性的Meta分析，中國優生與遺傳雜志，2012,(04):29-31。
(13)景永茂#，劉靜，李曙晶，史衛?。?strong>成曉龍*，COX-2啟動子區遺傳變異與胃癌發病風險的關系，中國優生與遺傳雜志，2012,(05):24-25。
(14)劉靜#，李曙晶，史衛?。?strong>成曉龍*，凋亡通路Fas/Fasl遺傳變異與胃癌發病
風險的關系，中國優生與遺傳雜志，2012,(08):28-30。
2.第一作者論文
(1)Jing Liu#, Yanyan Zhang#,Xiaolong Cheng#, Shujing Li, Heyang Cui,LingZhang,RuyiShi,ZhipingZhao,ChantingHe,ChuanguiWang, HaoliangZhao,CeZhang,Fisk HA,Guadagno TM,YongpingCui*,Phosphorylation ofMps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosomeinstability in melanoma,Oncogene,2013,32:713-723.
(2)XiaolongCheng#,Shih-HsinLu,YongpingCui*,ECRG2 regulatesECM degradation and uPAR/FPRL1 pathway contributing cellinvasion/migration，Cancer Letters,2010,290(1):87-95.
(3)Xiaolong Cheng#*,HuapingZhang,DongxingGuo,ZhongdongQiao,UPREGULATION OF FAS AND FASL EXPRESSION IN NICOTINE-INDUCED APOPTOSIS OFENDOTHELIAL CELLS，Methods and Findings in Experimental and ClinicalPharmacology,2010,32(1):13-18.
(4)Xiaolong Cheng#,ZhengShen,LitianYin,Shih-HsinLu,YongpingCui*,ECRG2 Regulates Cell Migration/Invasion through Urokinase-typePlasmin Activator Receptor (uPAR)/beta 1 Integrin Pathway,Journal ofBiological Chemistry.2009,284(45):30897-30906.
(5)XiaolongCheng#,ZhengShen,JianyiYang,Shih-HsinLu,YongpingCui*,ECRG2 disruption leads to centrosome amplification and spindlecheckpoint defects contributing chromosome instability,Journal of BiologicalChemistry,2008,283(9):5888-5898.
3.既非第一作者又非通信作者論文
(1) Ting Yan#，Heyang Cui#，Yong Zhou#，Bin Yang#，Pengzhou Kong#，Yingchun Zhang#，Yiqian Liu，Bin Wang，Yikun Cheng，Jiayi Li，Shixing Guo，Enwei Xu，Huijuan Liu，Caixia Cheng，Ling Zhang，Ling Chen，Xiaofei Zhuang，Yu Qian，Jian Yang，Yanchun Ma，Hongyi Li，Fang Wang，Jing Liu，Xuefeng Liu，Dan Su，Yan Wang，Ruifang Sun，Shiping Guo，Yaoping Li，Xiaolong Cheng，Zhihua Liu，Qimin Zhan*，and Yongping Cui*.Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma. Nature Communications. 2019, Apr 11;10(1):1670.
(2)Yanchun Ma#，Yi Wang#，Lu Wang，Yu Qian，Jian Yang，Pengzhou Kong，Ting Yan，Hongyi Li，Fang Wang，Xiaolong Cheng，Yongping Cui*.Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway. Eur J Pharmacol. 2019 May 15;851:43-51.
(3)Yanghui Bi#, Pengzhou Kong#, Ling Zhang#, Heyang Cui#, Xiaoqin Xu#, Feiyun Chang#, Ting Yan, Jiayi Li, Caixia Cheng, Bin Song, Xia Niu, Xiangchen Liu, Xue Liu, Enwei Xu, Xiaoling Hu, Yu Qian, Fang Wang, Hongyi Li, Yanchun Ma, Jian Yang, Yiqian Liu, Yuanfang Zhai, Yi Wang, Yingchun Zhang, Haiyan Liu, Jing Liu, Jintao Wang*,Yongping Cui,Xiaolong Cheng. EP300 as an oncogene correlates with poor prognosis in esophageal squamous carcinoma.J Cancer. 2019 Aug 29;10(22):5413-5426.
(4)JieYang#, PengzhouKong#, JianYang#, ZhiwuJia#, XiaolingHu, Zianyi Wang, HeyangCui, YanghuiBi, YuQian, Hongyi Li,Fang Wang, Bin Yang, Ting Yan, Yanchun Ma, Ling Zhang, Caixia Cheng, Bin Song, Yaoping Li, Enwei Xu, Haiyan Liu, Wei Gao, Juan Wang, Yiqian Liu, Yuanfang Zhai, , Lu Chang, Yi Wang, Yingchun Zhang, Ruyi Shi, Jing Liu, Qi Wang,Xiaolong Cheng, Yongping Cui*,High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC, Technology Cancer Research&Treatment, 2018,17:1-9.
(5)YikeLi#, YanyanZhang#, ShuaishuaiXiao, PengzhouKong,CaixiaCheng, RuyiShi, FangWang, LingZhang, JuanWang, ZhiwuJia, ShuaiWu, YunLiu, JianshengGuo,XiaolongCheng, YongpingCui*, JingLiu*, Mps1 is associated with the BRAFV600E mutation but does not rely on the classic RAS/RAF/MEK/ERK signaling pathway in thyroid carcinoma, Oncology Letters, 2018;15(6):9978-9986.
(6)BinYang#, TingYan#, HeyangCui#, EnweiXu#, YanchunMa#, CaixiaCheng#, LingZhang, PengzhouKong, FangWang, YuQian, JianYang, YaopingLi, HongyiLi, YanghuiBi, XiaolingHu, JuanWang, BinSong, JieYang, WeiGao, JingLiu, BinbinZou, RuyiShi, YanyanZhang, HaiyanLiu, YiqianLiu, YuanfangZhai, LuChang, YiWang, YingchunZhang, ZhiwuJia, XingChen, YanfengXi, GuodongLi, JianfangLiang, JianshengGuo, ShipingGuo, RongshengZhang,XiaolongCheng, YongpingCui*, The macro-evolutionary events in esophageal squamous cell carcinoma. Oncotarget, 2017; 8(68):112770-112782.
(7)XiaolingHu#, YuanfangZhai#, PengzhouKong#, HeyangCui#, TingYan, JianYang,YuQian , YanchunMa,FangWang , HongyiLi, CaixiaCheng, LingZhang, ZhiwuJia, YaopingLi, BinYang, EnweiXu, JuanWang , JieYang,YanghuiBi ,LuChang , YiWang, YingchunZhang, BinSong, GuodongLi, RuyiShi, Jing Liu, MingshengZhang,XiaolongCheng, YongpingCui*, FAT1 prevents epithelial mesenchymal transition (EMT) via MAPK/ERK signaling pathway in esophageal squamous cell cancer, Cancer letters, 2017; 397:83-93.
(8)Caixia Cheng#,YongZhou#,HongyiLi#,TengXiong#,ShuaichengLi#,YanghuiBi#,PengzhouKong,FangWang,HeyangCui,YaopingLi,XiaodongFang,TingYan, YikeLi,JuanWang,BinYang,LingZhang,ZhiwuJia,BinSong,XiaolingHu,JieYang,HaileQiu,GehongZhang,JingLiu,EnweiXu,RuyiShi,YanyanZhang, Haiyan Liu,ChantingHe,ZhenxiangZhao,YuQian,RuizhouRong,ZhiweiHan,YanlinZhang,WenLuo,JiaqianWang,ShaoliangPeng,XukuiYang,XiangchunLi, LinLi,HuFang,XingminLiu,LiMa,YunqingChen,ShipingGuo,XingChen,YanfengXi,GuodongLi, Jianfang Liang,XiaofengYang,JianshengGuo,JunMeiJia,QingshanLi,XiaolongCheng,QiminZhan*,YongpingCui*,Whole-Genome Sequencing Reveals Diverse Models of StructuralVariations in Esophageal Squamous Cell Carcinoma,American Journal of HumanGenetics,2016,98(2):256-274.
(9)Bin Song#,HeyangCui#,YaopingLi#,CaixiaCheng#,BinYang#,FangWang#,PengzhouKong#,HongyiLi,LingZhang,ZhiwuJia,YanghuiBi,JiaqianWang,YongZhou,JingLiu,JuanWang,ZhenxiangZhao,YanyanZhang,Xiaoling Hu, RuyiShi, JieYang,HaiyanLiu,TingYan,YikeLi,EnweiXu,YuQian,YanfengXi,ShipingGuo ,YunqingChen,JinfenWang,GuodongLi,JianfangLiang,JunmeiJia,XingChen,JianshengGuo,TongWang,YanboZhang,QingshanLi,ChuanguiWang,XiaolongCheng,QiminZhan*,Yongping Cui*,Mutually exclusive mutations in NOTCH1 and PIK3CA associated with clinicalprognosis and chemotherapy responses of esophageal squamous cell carcinoma inChina，Oncotarget，2016，7（3）：3599-3613.
(10)Caixia Cheng#,HeyangCui#,Ling Zhang#,ZhiwuJia#,BinSong#,FangWang#,YaopingLi,JingLiu,PengzhouKong,RuyiShi,YanghuiBi,BinYang, JuanWang,ZhenxiangZhao,YanyanZhang,XiaolingHu,JieYang,ChantingHe, ZhipingZhao,JinfenWang,YanfengXi,EnweiXu,GuodongLi,ShipingGuo,YunqingChen,XiaofengYang,XingChen,JianfangLiang,JianshengGuo,XiaolongCheng,ChuanguiWang,QiminZhan*,YongpingCui*,Genomicanalyses reveal FAM84B and NOTCH pathway relate to the progression ofesophageal squamouscell carcinoma,GigaScience,2016,5(1):1-13.
(11)Ling Zhang#,YongZhou#,CaixiaCheng#,HeyangCui#,LeCheng#,PengzhouKong#,JiaqianWang#,YinLi#,WenliangChen,BinSong,FangWang,ZhiwuJia,LinLi,YaopingLi,Bin Yang,JingLiu,RuyiShi,YanghuiBi,Yanyan Zhang,JuanWang,ZhenxiangZhao,XiaolingHu,Jie Yang,HongyiLi,ZhiboGao,GangChen,XuanlinHuang,XukuiYang,ShengqingWan,ChaoChen,BinLi,Yongkai Tan,LongyunChen,MinghuiHe,ShaXie,XiangchunLi,XuehanZhuang,MengyaoWang,ZhiXia, LonghaiLuo,JieMa,BingDong,JiuzhouZhao,YongmeiSong,YunweiOu,EnmingLi,LiyanXu,JinfenWang,YanfengXi,GuodongLi,EnweiXu,JianfangLiang, XiaofengYang,JianshengGuo,XingChen,YanboZhang,QingshanLi,LixinLiu,YingruiLi,XiuqingZhang,Huanming Yang,DongxinLin,XiaolongCheng,YongjunGuo,JunWang,QiminZhan*,Yongping Cui*,Genomic analyses reveal mutationalsignatures and frequently altered genes in esophageal squamous cellcarcinoma,American Journal of HumanGenetics,2015,96(4):597-611.
(12)Ling Zhang#,RuyiShi#,ChantingHe#,CaixiaCheng,BinSong,HeyangCui, YanyanZhang,ZhipingZhao,YanghuiBi,XiaofengYang,XiaopingMiao,JianshengGuo,XingChen,JinfenWang,YaopingLi,XiaolongCheng,JingLiu*,YongpingCui*,Oncogenic,B-Raf(V600E)abrogates the AKT/B-Raf/Mps1 interaction in melanoma cells,CancerLetters,2013,337(1):125-132.
(13) LiLu#*,HuifangSong,WeiguoZhang,XueqinLiu,QianZhu,XiaolongCheng, GuiJiaoYang,AngLi,ZhichengXiao*,Potential role of 20Sproteasome in maintaining stem cell integrity of human bone marrow stromalcells in prolonged culture expansion,Biochemical and Biophysical ResearchCommunications,2012,422(1):121-127.
(14)YongpingCui#*,XiaolongCheng,CeZhang,YanyanZhang,ShujingLi,ChuanguiWang,GuadagnoThomas M,Degradation of the Human MitoticCheckpoint Kinase Mps1 Is Cell Cycle-regulated by APC-c(Cdc20) and APC-c(Cdh1)Ubiquitin Ligases,Journal of BiologicalChemistry,2010,285(43):32988-32998.
(15)ZiYan#,FengLiang#,LiGuo,JinWang,XiaoliangWang,XiaolongCheng,XinliangMa,HuirongLiu*,Myeloperoxidase increasedcardiomyocyte protein nitration in mice subjected to nonlethal mechanicaltrauma,Biochemical and Biophysical ResearchCommunications,2010,393(3):531-535.
獲得學術獎勵
成曉龍（6/7），食管鱗癌遺傳變異的分析鑒定及癌變機制研究，中國抗癌協會，2017年度中國抗癌協會科技獎，二等獎，2018
（崔永萍、閻婷、孔鵬洲、張玲、程彩霞、成曉龍、錢鈺）
成曉龍，國家自然科學基金委員會榮譽證書，2016
