劉良坡

c7c7.app衛檢教研室主任，國家人體生物監測項目重點實驗室負責人

理學博士，副教授，碩士生導師，c7c7.app公共衛生學院，衛生檢驗與檢疫教研室

辦公電話：0351-4135167，15105973916

E-mail: lpliu@sxmu.edu.cn，

通信地址：c7c7.app公共衛生學院，山西省太原市新建南路56，030001

工作經歷：

2019.10-至今， c7c7.app，公共衛生學院，副教授/碩士生導師

2018.1-2019.9， 中國科學院城市環境研究所，城市環境和健康重點實驗室，副研究員/碩士生導師

2012.8-2017.12，中國科學院城市環境研究所，城市環境和健康重點實驗室，助理研究員

學習經歷：

2016.5-2017.5，美國Emory大學公共衛生學院，訪問學者，合作導師Dana Boyd Barr教授

教學情況：

主要承擔衛生檢驗與檢疫本科生的《儀器分析》和《化妝品檢驗與安全性評價》，預防醫學本科生的《衛生化學》，研究生《衛生檢驗學》課程，主持省級教改項目1項。

研究領域：

主要包括：1.環境污染物的檢測與生物監測技術；2.新興環境污染物（塑料添加劑、全氟化合物、阻燃劑等）的人群暴露途徑、體內轉化與健康效應；3.環境內分泌干擾物的生殖發育毒性與分子機理。截至2020年底，先后主持國家自然基金青年項目、福建省自然科學項目、天津市環境營養與健康重點實驗室開放課題和多項橫向課題。作為骨干成員參與國家自然科學基金、國家重點研發計劃、中國院“百人計劃”項目等各類省部級項目多項。以第一或通訊作者發表SCI論文16篇，合作發表論文40余篇，授權國家實用新型專利3項。

代表性科研項目：

1.中國疾控預防控制中心環境污染健康影響人體生物監測體系建設項目，中國疾控預防控制中心環境與健康相關產品安全所。2021.1-至今，59萬。在研，主持。

2.中國疾控中心人體生物樣本中化學污染物檢測方法驗證，中國疾病預防控制中心，2024，在研，主持。

3.山西省應用基礎研究計劃面上項目，PFOS及新型替代物的跨胎盤轉移規律及胎盤毒性研究，山西省科技廳，2023.1-2025.12，9萬，在研，主持

4.c7c7.app人才引進啟動基金，胎兒期典型鄰苯二甲酸酯暴露對男嬰微小青春期激素分泌的影響及機制研究，2019，40萬，在研，主持。

5.天津市環境營養與人群健康重點實驗室開放課題，2020ENKL08,全氟化合物暴露與2型糖尿病關聯性研究，2021.1-2022.12，已結題，主持。

6．國家自然科學基金青年項目，21407144，嬰幼兒不同發育階段鄰苯二甲酸酯的暴露負荷及代謝特征研究，2015.1-2017.12，26萬，已結題，主持。

7．福建省自然科學基金計劃項目，2015J05038，炔雌醇對嬰幼兒下丘腦垂體性腺軸的內分泌干擾作用研究，2015.4-2018.4，4萬，已結題，主持。

代表性論著：

1.Liangpo Liu, Peixia Yan, Xuan Liu, Junxia Zhao, Meiping Tian, Qingyu Huang, Jianbo Yan, Zhendong Tong, Yongli Zhang, Jie Zhang, Tongjie Zhang, Jianquan Guo, Guiying Liu, Xia Bian, Ben Li, Tong Wang, Heng Wang, Heqing Shen*. Profiles and transplacental transfer of Per- and Polyfluoroalkyl Substances in maternal and umbilical cord blood: A birth cohort study in Zhoushan, Zhejiang Province, China. Journal of Hazardous Materials, 2024，466,133501.

2. Xiujuan Yang1,2*?, Bijun Cheng1?, Yi Gao3, Hongmei Zhang4 andLiangpo Liu*. Heavy metal contamination assessment and probabilistic health risks in soil and maize near coal mines. Frontiers in Public Health, 2022, DOI 10.3389/fpubh.2022.1004579.

3.Liangpo Liu*, Peixia Yan, Jifang Lv, Xuan Liu, Junxia Zhao, Jianquan Guo, Guiying Liu, Xia Bian, Linying Gao, Wei Yan, Qiansheng Huang, Guixia Chen*. Optimization and application of a method to determine 24 perfluorinated compounds in umbilical cord serum by using liquid chromatography tandem mass spectrometry, Journal of Chromatography B, 2022, 1207:123365.

4.Liangpo Liu^*, Heng Wang, Xueyan Li, Meiping Tian, Qingyu Huang, Jie Zhang, Hong Pan, Kai Wen, Qiansheng Huang, Jianbo Yan, Zhendong Tong, Yongli Zhang,Tongjie Zhang, Yingying Zhang, Ben Li, Tong Wang, Heqing Shen*. Infantile phthalate metabolism and toxico/pharmacokinetic implications within the first year of life. Environment International, 2020, 144, 106052.

5.Liangpo Liu, Huaqiong Bao, Feng Liu, Jie Zhang, Heqing Shen^*. Phthalates exposure of Chinese reproductive age couples and its effect on male semen quality, a primary study. Environment International, 2012, 42, 78-83.

6.Liangpo Liu, Heng Wang, Meiping Tian, Jie Zhang, Parinya Panuwet, Priya Esilda D'Souza, Dana Boyd Barr, Qingyu Huang, Yankai Xia, Heqing Shen^*. Phthalate metabolites related to infertile biomarkers and infertility in Chinese men. Environmental Pollution, 2017, 231:291-300.

7.Liangpo Liu, Tongwei Xia, Xueqin Zhang, Dana Boyd Barr, Ambreen Alamdar, Jie Zhang, Meiping Tian, Qingyu Huang, Heqing Shen*. Biomonitoring of infant exposure to phenolic endocrine disruptors using urine expressed from disposable gel diapers. Analytical and Bioanalytical Chemistry, 2014, 406: 5049-5054.

8.Liangpo Liu, Tongwei Xia, Lihua Guo, Lanyu Cao, Benhua Zhao, Jie Zhang, Sijun Dong, Heqing Shen^*. Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example. Journal of Exposure Science and Environmental Epidemiology, 2012, 22, 625-631.

9.Liangpo Liu, Jianwen She, Xueqin Zhang, Jie Zhang, Meiping Tian, Qingyu Huang, Shah Eqani, Syed Ali Musstjab Akber, Heqing Shen^*. Online background cleanup followed by high-performance liquid chromatography with tandem mass spectrometry for the analysis of perfluorinated compounds in human blood. Journal of Separation Science, 2015, 38 (2): 247-253.

10.Liangpo Liu, Ailing Sun, Sujuan Wu and Renmin Liu^*. 2009. Preparative Purification of Morroniside and Loganin from Fructus corni by Combination of Macroporous Absorption Resin and HSCCC. Journal of Chromatographic Science, 47 (2009): 333-336.

11. Qingyu Huang^#,Liangpo Liu^#, Yan Wu, Xiaofei Wang, Lianzhong Luo, Bingru Nan, Jie Zhang, Meiping Tian, Heqing Shen^*. Seminal plasma metabolites mediate the associations of multiple environmental pollutants with semen quality in Chinese men. Environment International, 2019, 132, 105066. (JCR 1區，IF 7.577,并列一作)

12. Xueyan Li^#,Liangpo Liu^#, Heng Wang, Xueqin Zhang, Tonghu Xiao*, Heqing Shen*. Phthalate Exposure and Cumulative Risk in a Chinese Newborn Population. Environmental Science and Pollution Research, 2019, 26 (8):7763-7771. (并列一作)

13. Xiaofei Wang^#,Liangpo Liu^#, Weibing Zhang^*, Jie Zhang, Xiaoyan Du, Qingyu Huang, Meiping Tian, Heqing Shen^*. Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative nitrosative stress in humans. Environmental Pollution, 2017, 229:168-176. (JCR 1區，IF 6.792,并列一作)

14. Heng Wang^#,Liangpo Liu^#, Jianyue Wang, Zhendong Tong, Jianbo Yan, Tongjie Zhang, Ying Qin, Tingting Jiang, Jianwen She, Heqing Shen^*, Urinary sexual steroids associated with bisphenol A (BPA) exposure in the early infant stage: preliminary results from a Daishan birth cohort. Science of the Total Environment, 2017, 601-602:1733-1742. (JCR2區，IF 6.551,并列一作)

15. Siyuan Peng^#,Liangpo Liu^#, Xueqin Zhang, Heinrich J，Zhang J, Schramm K-W, Qiangyu Huang, Huang, Eqani Samas, Heqing Shen^*. A Nested Case-Control Study Indicating Heavy Metal Residues in Meconium Associate with Maternal Gestational Diabetes Mellitus Risk, Environmental Health, 2015, 14:19. (并列一作)

16. Heng Wang,Liangpo Liu^*, Syed Ali Musstjab Akber Shah Eqani, Heqing Shen^*, Infant exposure to bisphenol A can be quantitatively assessed by a simply improved high-performance liquid chromatography-tandem mass-spectrometry method. Analytical sciences, 2017, 33:777-781. (并列通訊)

已授權專利：

1.劉良坡,申河清,王展林。離心分離內插管，2012.3，中國，專利號：ZL 201220124423.0.