閻小艷

博士、教授、博士生導(dǎo)師

E-mail:yanxiaoyan@sxmu.edu.cn

教育工作經(jīng)歷：

2016/6-至今，c7c7.app，公共衛(wèi)生學(xué)院，教授

2014/11-2015/11，美國(guó)紐約州立大學(xué)，布法羅分校醫(yī)學(xué)院，訪問(wèn)學(xué)者

2010/03-2011/03，美國(guó)紐約州立大學(xué)，布法羅分校醫(yī)學(xué)院，博士后

2008/12-2016/06，太原師范學(xué)院，副教授

2003/07–2008/07，山西農(nóng)業(yè)大學(xué)，碩博連讀

學(xué)術(shù)任職

山西省優(yōu)秀青年學(xué)術(shù)帶頭人，山西省科技廳優(yōu)青項(xiàng)目負(fù)責(zé)人，山西省青年科技協(xié)會(huì)常務(wù)理事，中國(guó)環(huán)境誘變劑學(xué)會(huì)青年委員會(huì)青年委員，中國(guó)環(huán)境誘變劑學(xué)會(huì)環(huán)境應(yīng)激與健康損害專委會(huì)委員。

榮譽(yù)獲獎(jiǎng)

獲山西省優(yōu)秀博士學(xué)位論文獎(jiǎng)1項(xiàng)，山西省教學(xué)成果二等獎(jiǎng)1項(xiàng)(第三名)，山西省高等學(xué)?？蒲а芯坑判慍曬保ㄗ勻豢蒲В┮壞冉?項(xiàng)(第二名)，山西省本科院校中青年教師基本功大賽二等獎(jiǎng)1項(xiàng)(二等功)，第十八屆山西省優(yōu)秀學(xué)術(shù)論文二等獎(jiǎng)1項(xiàng)(通訊作者)，山西省科學(xué)技術(shù)獎(jiǎng)（自然科學(xué)）省部二等獎(jiǎng)1項(xiàng)(第三名)。

教學(xué)情況

主持校教改課題1項(xiàng)，4項(xiàng)山西省大學(xué)生創(chuàng)新項(xiàng)目。

2019年與2021年指導(dǎo)的碩士研究生獲得山西省優(yōu)秀碩士論文，2020年、2021年、2022年指導(dǎo)的碩士研究生連續(xù)獲得c7c7.app優(yōu)秀碩士畢業(yè)生稱號(hào)。

研究領(lǐng)域

地方性氟中毒和砷中毒與人群健康。

代表性科研項(xiàng)目

1.山西省科學(xué)技術(shù)廳,自由探索類基礎(chǔ)研究, YDZJSX2024D064,腸道代謝物L(fēng)PS調(diào)控TLR4/NF-κB炎癥通路在砷氟暴露致心血管毒性中的機(jī)理研究, 2024-07至2027-06, 40萬(wàn)元,在研,主持；

2.國(guó)家自然科學(xué)基金，82173644，腸道菌群代謝物TMAO調(diào)控ROS/自噬通路在砷氟聯(lián)合暴露致心肌損傷中的機(jī)理研究，2022/01-2025/12，54萬(wàn)元，在研，主持；

3.探討砷誘導(dǎo)腸道菌群紊亂在不良心血管效應(yīng)(CVEs)中的重要作用。山西省高等學(xué)校青年科研人員培育計(jì)劃項(xiàng)目，2020.10-2021.10，10萬(wàn)元，在研，主持；

4.氟中毒對(duì)動(dòng)物心肌損傷的mRNA差異表達(dá)的分析。山西省回國(guó)留學(xué)人員科研資助項(xiàng)目，2017-058，2017.07-2020.07，3萬(wàn)元，已結(jié)題，主持；

5.內(nèi)質(zhì)網(wǎng)應(yīng)激通過(guò)調(diào)控ROS和Ca2+的水平在氟致心肌細(xì)胞凋亡中發(fā)揮重要作用。山西省優(yōu)秀青年基金項(xiàng)目，201701D211008，2017.07-2019.12，15萬(wàn)元，已結(jié)題，主持；

6.氟中毒對(duì)動(dòng)物心肌損傷的調(diào)控機(jī)理研究。山西省優(yōu)秀青年學(xué)術(shù)帶頭人基金，2017.01-2019.12，10萬(wàn)元，已結(jié)題，主持；

7.基于轉(zhuǎn)錄組學(xué)分析氟中毒對(duì)動(dòng)物心肌損傷的調(diào)控機(jī)理研究。中國(guó)博士后面上一等資助，2016M600199，2016.11-2018.12，8萬(wàn)元，已結(jié)題，主持；

8.基于線粒體蛋白質(zhì)組學(xué)的氟中毒小鼠心肌功能損傷的分子機(jī)制研究。國(guó)家自然科學(xué)基金項(xiàng)目，31302158，2014.01-2016.12，23萬(wàn)元，已結(jié)題，主持；

9.氟誘導(dǎo)心肌細(xì)胞ROS在線粒體和MAPK信號(hào)轉(zhuǎn)導(dǎo)通路中的機(jī)理。國(guó)家自然科學(xué)基金項(xiàng)目，31240009，2013.01-2013.12，15萬(wàn)元，已結(jié)題，主持。

代表性論著

1.閻小艷，參編 《健康人文-營(yíng)養(yǎng)衛(wèi)生篇》.人民衛(wèi)生出版社，北京，2017.10，ISBN 978-7-117-25261-4/R?25262

2.閻小艷，參編《環(huán)境與健康》，人民教育出版社，

3.閻小艷，參編《環(huán)境獸醫(yī)學(xué)》，中國(guó)農(nóng)業(yè)出版社，

4. Xiaolin Tian, Meng Wang, Xiaodong Ying, Nisha Dong, Meng Li, Jing Feng, Yannan Zhao, Qian Zhao, Fengjie Tian, Ben Li, Wenping Zhang, Yulan Qiu, Xiaoyan Yan*. Co-exposure to arsenic and fluoride to explore the interactive effect on oxidative stress and autophagy in myocardial tissue and cell，Ecotoxicology and Environmental Safety, 2023, 253:114647.

5. Zhijia Guo*, Meng Wang, Xiaodong Ying, Jiyu Yuan, Chenggang Wang, Wenjie Zhang, Shouyuan Tian, Xiaoyan Yan*.Caloric restriction increases the resistance of aged heart to myocardial ischemia/reperfusion injury via modulating AMPK–SIRT1–PGC1a energy metabolism pathway,Scientific reports, 2023, 13:2045.

6Qiang Su; Meng Li; Lingling Yang; Linhua Fan; Penghui Liu; Xiaodong Ying; Yannan Zhao;Xiaolin Tian; Fengjie Tian; Qian Zhao; Ben Li; Yi Gao; Yulan Qi; Guohua Song; Xiaoyan Yan ;ASC/Caspase-1-activated endothelial cells pyroptosis is involved in vascular injury induced byarsenic combined with high-fat diet,Toxicology, 2023,500(153691)

7. Meng Li#; Jing Feng#; Ying Cheng; Nisha Dong; Xiaolin Tian; Penghui Liu; Yannan Zhao; Yulan Qiu; Fengjie Tian; Yi Lyu; Qian Zhao; Cailing Wei; Meng Wang; Jiyu Yuan; Xiaodong Ying; Xuefeng Ren*; Xiaoyan Yan*; Arsenic-fluoride co-exposure induced endoplasmic reticulum stress resulting in apoptosis in rat heart and H9c2 cells,Chemosphere, 2022, 288:132518.

8. Penghui Liu#, Ran Li#, Xiaolin Tian, Yannan Zhao, Meng Li, Meng Wang, Xiaodong Ying, Jiyu Yuan, Jiaxin Xie, Xiaoting Yan, Yi Lyu, Cailing Wei, Yulan Qiu, Fengjie Tian, Qian Zhao, Xiaoyan Yan*; Co-exposure to fluoride and arsenic disrupts intestinal flora balance and induces testicular autophagy in offspring rats,Ecotoxicology and Environmental Safety, 2021, 222:112506.

9.Xiaoyan Yan*,Xushen Chen, Xiaolin Tian, Yulan Qiu, Jie Wang, Guan Yu, Nisha Dong, Jing Feng, Jiaxin Xie, Morgan Nalesnik, Ruiyan Niu, Bo Xiao, Guohua Song, Sarah Quinones, Xuefeng Ren,. Co-Exposure to Inorganic Arsenic and Fluoride Prominently Disrupts Gut Microbiota Equilibrium and Induces Adverse Cardiovascular Effects in Offspring Rats.Science of the Total Environment. 2021, 767: 144924.

10.Yannan Zhao, Meng Li, Xiaolin Tian, Jiaxin Xie, Penghui Liu, Xiaodong Ying, Meng Wang, Jiyu Yuan, Yi Gao, Fengjie Tian,Xiaoyan Yan*. Effects of Arsenic Exposure on Lipid Metabolism: A Systematic Review and Meta-analysis.Toxicology Mechanisms and Methods. 2021, 31(3): 188-196.

11.Meng Li, Yannan Zhao, Xiaolin Tian, Penghui Liu, Jiaxin Xie, Nisha Dong, Jing Feng, Yi Gao, Ye Fan, Yulan Qiu, Fengjie Tian,Xiaoyan Yan*. Fluoride Exposure and Blood Pressure: a Systematic Review and Meta-Analysis. Biological Trace Element Research. 2021, 199(3): 925-934.

12.Jiaxin Xie, Xiaoting Yan, Guoqiang Xu, Xiaolin Tian, Nisha Dong, Jing Feng, Penghui Liu, Meng Li, Yannan Zhao, Cailing Wei, Yi Lyu, Guijin Ma, Guohua Song, Tong Wang,Xiaoyan Yan*. ITRAQ-based proteomics reveals the potential mechanism of fluoride-induced myocardial contraction function damage.Ecotoxicology and Environmental Safety. 2020, 197: 110605.

13.Nisha Dong, Jing Feng, Jiaxin Xie, Xiaolin Tian, Meng Li, Penghui Liu, Yannan Zhao, Cailing Wei, Yi Gao, Ben Li, Yulan Qiu,Xiaoyan Yan*. Co-exposure to Arsenic-Fluoride Results in Endoplasmic Reticulum Stress-Induced Apoptosis Through the PERK Signaling Pathway in the Liver of Offspring Rats. Biological Trace Element Research. 2020, 197: 192-201.

14.Xiaolin Tian, Jiaxin Xie, Xushen Chen, Nisha Dong, Jing Feng, Yi Gao, Fengjie Tian, Wenping Zhang, Yulan Qiu, Ruiyan Niu, Xuefeng Ren,Xiaoyan Yan*. Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring.Archives of Toxicology. 2020, 94(3): 749-60.

15.Xiaoyan Yan, Nisha Dong, Xianhui Hao, Yangang Xing, Xiaolin Tian, Jing Feng, Jiaxin Xie, Yi Lv, Cailing Wei, Yi Gao, Yulan Qiu, Tong Wang*. Comparative Transcriptomics Reveals the Role of the Toll-Like Receptor Signaling Pathway in Fluoride-Induced Cardiotoxicity.Journal of Agricultural and Food Chemistry. 2019, 67(17): 5033-42.

16.Xiaolin Tian, Jing Feng, Nisha Dong, Yi Lyu, Cailing Wei, Ben Li, Yanqin Ma, Jiaxin Xie, Yulan Qiu, Guohua Song, Xuefeng Ren,Xiaoyan Yan*. Subchronic exposure to arsenite and fluoride from gestation to puberty induces oxidative stress and disrupts ultrastructure in the kidneys of rat offspring.Science of the Total Environment. 2019, 686: 1229-37.

17.Jing Feng, Yang Meng, Xiaozhu Wang, Zhaoyang Chen,Xiaoyan Yan*. Reactive oxygen species, nitric oxide, and intracellular Ca2+ participate in fluoride-induced yeast cell death. Fluoride. 2019, 53(1 Pt 1): 40-51.

18.Xiaoyan Yan, Lu Wang, Xia Yang, Yulan Qiu, Xiaolin Tian, Yi Lv, Fengjie Tian, Guohua Song, Tong Wang*. Fluoride induces apoptosis in H9c2 cardiomyocytes via the mitochondrial pathway. Chemosphere. 2017, 182: 159-165.

19.Xiaoyan Yan, Xiaolin Tian, Lu Wang, Wenli Zhou, Wenyan Zhang, Yi Lv, Yulan Qiu, Tong Wang*. Fluoride induces apoptosis in MC3T3-E1 osteoblasts by altering ROS levels and mitochondrial membrane potentials. Fluoride. 2017, 50(2): 213–22.

國(guó)內(nèi)外參與的學(xué)術(shù)會(huì)議

在學(xué)習(xí)和研究期間，曾赴多地參加多次國(guó)際學(xué)術(shù)會(huì)議并做報(bào)告，在2024年赴丹麥參加第58屆歐洲毒理學(xué)學(xué)會(huì)大會(huì)，2012年和2013年分別赴波蘭和伊朗參加第30屆、第31屆國(guó)際氟化物學(xué)術(shù)研討會(huì)，在2014年至美國(guó)芝加哥參加美國(guó)心臟協(xié)會(huì)2014年科學(xué)年會(huì)，以及在2016年和2017年赴美國(guó)參加美國(guó)毒理學(xué)會(huì)第55屆和第56屆毒理學(xué)年會(huì)，2018年赴貴州參加第34屆國(guó)際氟化物學(xué)術(shù)研討會(huì)，2019年赴蘭州參加中第三次會(huì)議暨第四屆高校毒理學(xué)教育論壇，赴太原參加中國(guó)毒理學(xué)會(huì)第九次全國(guó)毒理學(xué)大會(huì)，赴昆明參加第十次全國(guó)地方病學(xué)術(shù)會(huì)議。2020年赴昆明參加中國(guó)毒理學(xué)會(huì)第七次中青年學(xué)者科技論壇。2022年赴哈爾濱參加第35屆國(guó)際氟化物學(xué)術(shù)研討會(huì)，赴長(zhǎng)治參加中國(guó)環(huán)境誘變劑學(xué)術(shù)研討會(huì)。2023年赴青島參加第七屆亞洲環(huán)境誘變劑學(xué)術(shù)大會(huì)、第十九屆中國(guó)環(huán)境誘變劑學(xué)會(huì)學(xué)術(shù)大會(huì)，赴珠海參加中國(guó)毒理學(xué)會(huì)第十次全國(guó)毒理學(xué)大會(huì)。